Valerio Leoni Selected Research

7-ketocholesterol

1/2021	7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19.
1/2020	The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients.
1/2017	Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors.
12/2016	Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice.
2/2005	Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis.

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Valerio Leoni Research Topics

Disease

15	Huntington Disease (Huntington's Disease) 11/2021 - 09/2007
13	Neoplasms (Cancer) 01/2022 - 02/2016
11	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021 - 11/2008
11	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 04/2006
8	Infections 05/2022 - 12/2008
8	Cognitive Dysfunction 10/2021 - 04/2006
7	Mitochondrial Diseases (Mitochondrial Disease) 11/2019 - 04/2014
6	Multiple Sclerosis 01/2021 - 10/2002
5	Hypercholesterolemia 10/2017 - 09/2010
5	Disease Progression 08/2015 - 11/2008
5	Atrophy 08/2015 - 01/2009
4	COVID-19 05/2022 - 01/2020
4	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 01/2017
3	Inflammation (Inflammations) 01/2019 - 07/2006
3	Demyelinating Diseases (Demyelinating Disease) 01/2019 - 04/2003
2	Obesity 01/2019 - 12/2016
2	Neoplasm Metastasis (Metastasis) 07/2018 - 01/2017
2	Myocardial Ischemia (Ischemic Heart Diseases) 10/2017 - 12/2016
2	Neuroinflammatory Diseases 07/2013 - 02/2005
1	Frailty 01/2022
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2021
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2021
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021
1	Chronic Hepatitis B 01/2021
1	Macular Degeneration (Age-Related Maculopathy) 01/2021
1	Common Cold 01/2020
1	Adrenocortical Carcinoma 01/2020
1	Relapsing-Remitting Multiple Sclerosis 11/2019
1	Hypertrophy 01/2019
1	Ischemia 10/2017
1	Carcinoma (Carcinomatosis) 01/2017
1	Rupture 01/2017

Drug/Important Bio-Agent (IBA)

27	CholesterolIBA 11/2021 - 02/2005
18	OxysterolsIBA 01/2022 - 10/2002
11	Biomarkers (Surrogate Marker)IBA 01/2021 - 04/2003
11	24-hydroxycholesterolIBA 04/2014 - 10/2002
7	Proteins (Proteins, Gene)FDA Link 10/2019 - 09/2007
6	27-hydroxycholesterolIBA 01/2022 - 01/2011
5	7-ketocholesterolIBA 01/2021 - 02/2005
5	LigandsIBA 10/2019 - 06/2013
5	Apolipoproteins E (ApoE)IBA 07/2013 - 09/2007
4	Antiviral Agents (Antivirals)IBA 01/2021 - 01/2017
4	human ERBB2 proteinIBA 01/2018 - 01/2017
3	VaccinesIBA 01/2022 - 01/2018
3	LipidsIBA 01/2021 - 03/2012
3	Adenosine Triphosphate (ATP)IBA 10/2018 - 04/2014
2	Biological ProductsIBA 01/2022 - 10/2007
2	Complement System Proteins (Complement)IBA 01/2021 - 11/2008
2	AntigensIBA 01/2021 - 10/2019
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 01/2019
2	Interleukin-12 (IL 12)IBA 01/2021 - 01/2018
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2019 - 10/2018
2	Cardiolipins (Cardiolipin)IBA 11/2019 - 10/2018
2	AcidsIBA 11/2019 - 01/2017
2	Messenger RNA (mRNA)IBA 10/2018 - 10/2007
2	Liver X ReceptorsIBA 07/2018 - 01/2017
2	Immune Checkpoint InhibitorsIBA 01/2018 - 01/2017
2	Acetyl Coenzyme A (Acetyl-CoA)IBA 08/2015 - 04/2014
2	ApolipoproteinsIBA 03/2011 - 09/2010
1	AntibodiesIBA 01/2022
1	BNT162 VaccineIBA 01/2022
1	Estrogen ReceptorsIBA 01/2022
1	Dopamine Receptors (Dopamine Receptor)IBA 11/2021
1	Hepatitis B e AntigensIBA 01/2021
1	CoagulantsIBA 01/2021
1	CytokinesIBA 01/2021
1	25-hydroxycholesterolIBA 01/2021
1	immune RNA (I-RNA)IBA 01/2021
1	Lipocalin-2IBA 01/2021
1	Mitotane (Lysodren)FDA Link 01/2020
1	Dimethyl FumarateIBA 11/2019
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 11/2019
1	Caspase 3 (Caspase-3)IBA 11/2019
1	citraconic acid (mesaconic acid)IBA 11/2019
1	IntegrinsIBA 10/2019
1	NeuropeptidesIBA 09/2019
1	Biotin (Vitamin H)FDA Link 01/2019
1	Anthocyanins (Anthocyanin)IBA 01/2019
1	tempolIBA 01/2019
1	Small Heat-Shock ProteinsIBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2019
1	PlasmalogensIBA 10/2018
1	EnzymesIBA 10/2018
1	Peptides (Polypeptides)IBA 01/2018
1	Single-Chain AntibodiesIBA 01/2018
1	4'-chlorodiazepamIBA 10/2017
1	SterolsIBA 10/2017
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2017
1	InterleukinsIBA 01/2017
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2017
1	TensinsIBA 01/2017
1	ProfilIBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	Tocopherols (Tocopherol)IBA 01/2017
1	Artificial ReceptorsIBA 01/2017

Therapy/Procedure

6	Therapeutics 05/2022 - 01/2013
2	Immunotherapy 10/2019 - 01/2018
1	Injections 10/2021
1	Prostatectomy (Retropubic Prostatectomy) 01/2019